Frank Mozzicatowas born on June 19, 2003, in Hartford, Connecticut, and grew up in nearby Ellington. He attended East Catholic High School in Manchester, Connecticut, where he focused on baseball and showed quick growth as a pitcher. During his senior year in 2021, he led his team to a Class M state championship with a perfect 25–0 season. He struck out 135 batters and posted a 0.16 earned run average over 55.2 innings, and threw four straight no-hitters in that period. That stretch included 49 and two-thirds innings without allowing a single run or hit, drawing national attention. Mozzicato had committed to play college baseball at UConn, but his performance elevated his status as a top prospect. In the 2021 MLB draft, the Kansas City Royals selected him seventh overall, making him the highest drafted Connecticut high school player since 1968, and he signed for a bonus reported at $3.55 million.
Frank Mozzicato pitched for East Catholic High School in Manchester, Connecticut, where he became known during his senior year in 2021. He led his team to a perfect 25–0 season and a Class M state championship. That season, he struck out 135 batters, posted an ERA of 0.16, and threw four straight no-hitters, going 49⅔ scoreless innings overall. In the state championship game, he struck out 17 batters and allowed just one hit while shutting out the opponent.
His dominant spring performance brought national attention. Scouts arrived in large numbers as his fastball climbed from the mid‑80s into the low‑90s. He paired that with a top-tier curveball considered among the best breaking balls in high school baseball. Despite being relatively unheralded at first, his consistent success paired with projection made him rise rapidly into first‑round draft consideration.
Mozzicato had previously committed to play college baseball at UConn, but after his record‑breaking high school run, he became one of the top high school pitching prospects in the 2021 MLB Draft and signed with the Kansas City Royals as the seventh overall pick, with a signing bonus of around $3.55 million.
Frank Mozzicato signed with the Kansas City Royals after being selected seventh overall in the 2021 MLB Draft and started his pro career in 2022 at Low-A Columbia, posting a 4.30 ERA with 89 strikeouts over 69 innings while still working on control. In 2023, he moved up to High‑A Quad City, experienced some early struggles, but ultimately improved to a 3.45 ERA with 91 strikeouts in 101⅔ innings, earning a Minor League Gold Glove Award in 2024 for defensive excellence and being rated the Royals' No. 10 prospect by Baseball America. In early 2025, he was named the Midwest League Pitcher of the Month for April after posting a 1.24 ERA and 37 strikeouts in 36⅓ innings with a 1.02 WHIP at Quad City, leading to a promotion to Double-A Northwest Arkansas. At Double-A, Mozzicato has faced challenges, including a higher ERA and more walks than strikeouts over his first eight outings, yet he earned a spot on the American League roster for the 2025 All-Star Futures Game.